Synthesis,  13 C‐NMR characterization and antimicrobial properties of a novel series of 3‐( N ‐Substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino‐[5,6‐ b ]indole derivatives | Zendy

Omar A.Mohsen M. E. | Zendy; Eshba Nabil H. | Zendy; Aboushleib Hamida M. | Zendy

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Synthesis, 13 C‐NMR characterization and antimicrobial properties of a novel series of 3‐( N ‐Substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino‐[5,6‐ b ]indole derivatives

Author(s) -

Omar A.Mohsen M. E.,

Eshba Nabil H.,

Aboushleib Hamida M.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230626

Subject(s) - chemistry , antimicrobial , indole test , candida albicans , escherichia coli , proton nmr , carbon 13 nmr , penicillin , stereochemistry , organic chemistry , microbiology and biotechnology , antibiotics , biochemistry , gene , biology

A series of 3‐( N ‐substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino[5,6‐ b ]indole derivatives 3–22 has been synthesized and evaluated for in vitro antimicrobial activity. Although some of the products displayed significant activity against Staphylococcus aureus, Escherichia coli and Candida albicans , their bactericidal and bacterostatic potencies were lower than that of penicillin G. The structure of the products was assigned upon the basis of their infrared, 1 H‐nmr and 13 C‐nmr spectra.

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