Synthesis of 5‐phenylnaphtho[1,2‐ b ]benzofuran by ambident alkylation of 1‐naphthol | Zendy

Campaigne E. | Zendy; Weddleton Richard F. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 5‐phenylnaphtho[1,2‐ b ]benzofuran by ambident alkylation of 1‐naphthol

Author(s) -

Campaigne E.,

Weddleton Richard F.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230604

Subject(s) - chemistry , alkylation , benzofuran , dehydrogenation , medicinal chemistry , alcohol , ether , organic chemistry , catalysis

Reaction of 1‐naphthol with 2‐chlorocyclohexanone in alkaline alcohol gave as the major product 5‐(2′‐oxocyclohexyl)‐7,8,9,10‐tetrahydronaphtho[1,2‐ b ]benzofuran ( 1 ), which could be converted to the title compound 5 by reduction and dehydrogenation. This product arises from ambident alkylation of 1‐naphthol at the 2‐and 4‐positions. Via the 2′‐oxocyclohexyl ether, 5 was also synthesized from 4‐phenyl‐1‐naphthol.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research