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Acyclopyrimidine C ‐nucleosides: Synthesis of 5‐[(2,3‐dihydroxy‐1‐propoxy)methyl]pyrimidines
Author(s) -
Chu Chung K.,
Suh Jungjin
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230603
Subject(s) - chemistry , uracil , derivative (finance) , ring (chemistry) , condensation , transformation (genetics) , medicinal chemistry , organic chemistry , dna , biochemistry , physics , gene , financial economics , economics , thermodynamics
From the condensation of 5‐hydroxymethyluracil and glycerine, 5‐[(2,3‐dihydroxy‐1‐propoxy)methyl]uracil ( 3 ) was synthesized, which was converted to the isocytosine derivative 9 by the ring‐transformation reaction via dimethyluracil derivative 7 .