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Synthesis and stereochemistry of tetrahydroprotoberberine derivatives
Author(s) -
Badia D.,
Domínguez E.,
Iriondo C.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230568
Subject(s) - chemistry , diastereomer , alkylation , stereochemistry , organic chemistry , catalysis
A series of 5‐hydroxytetrahydroprotoberberines has been prepared from 3‐aryltetrahydroisoquinoline derivatives via successive N ‐alkylation, oxidation and cyclization in acidic media. The relative configurations of the resulting diastereomeric 5‐hydroxytetrahydroprotoberberines are reported.