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The synthesis of dimethoxy[1]benzothieno[2,3‐ c ]quinolines
Author(s) -
Pakray Sudabeh,
Castle Raymond N.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230563
Subject(s) - chemistry , thiophene , lactam , stereochemistry , medicinal chemistry , organic chemistry
A series of dimethoxy[1]benzothieno[2,3‐ c ]quinolines have been prepared by photocyclization of the appropriate N ‐phenyl‐3‐chlorobenzo[ b ]thiophene‐2‐carboxamides. The lactams obtained were converted into the thiolactams and their S ‐methyl derivatives. The lactams were also converted into the corresponding chloro derivatives which were catalytically dechlorinated into the dimethoxy[1]benzothieno[2,3‐ c ]quinolines. The latter compounds were converted into the N ‐methyl quaternary salts.