Pyrrolopyridine analogs of nalidixic acid. 2. Pyrrolo[3,4–6]pyridines | Zendy

Toja Emilio | Zendy; Kettenring Jurgen | Zendy; Goldstein Beth | Zendy; Tarzia Giorgio | Zendy

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Pyrrolopyridine analogs of nalidixic acid. 2. Pyrrolo[3,4–6]pyridines

Author(s) -

Toja Emilio,

Kettenring Jurgen,

Goldstein Beth,

Tarzia Giorgio

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230561

Subject(s) - chemistry , nalidixic acid , pyridine , stereochemistry , antibacterial activity , in vitro , ethyl ester , carboxylic acid , carboxylate , medicinal chemistry , organic chemistry , antibiotics , bacteria , biochemistry , antibiotic resistance , biology , genetics

The synthesis of the new 1‐ethyl‐5,6‐dimethyl‐7‐(4‐methyl‐1‐piperazinyl)‐1,4‐dihydro‐4‐oxo‐1 H ‐pyrrolo[3,4‐ b ] pyridine‐3‐carboxylic acid ( 12 ) was carried out using ethyl 4‐amino‐2‐methyipyrrole‐3‐carboxylate as the starting material. Compound 12 was devoid of antibacterial activity in vitro .

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