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Pyrrolopyridine analogs of nalidixic acid. 2. Pyrrolo[3,4–6]pyridines
Author(s) -
Toja Emilio,
Kettenring Jurgen,
Goldstein Beth,
Tarzia Giorgio
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230561
Subject(s) - chemistry , nalidixic acid , pyridine , stereochemistry , antibacterial activity , in vitro , ethyl ester , carboxylic acid , carboxylate , medicinal chemistry , organic chemistry , antibiotics , bacteria , biochemistry , antibiotic resistance , biology , genetics
The synthesis of the new 1‐ethyl‐5,6‐dimethyl‐7‐(4‐methyl‐1‐piperazinyl)‐1,4‐dihydro‐4‐oxo‐1 H ‐pyrrolo[3,4‐ b ] pyridine‐3‐carboxylic acid ( 12 ) was carried out using ethyl 4‐amino‐2‐methyipyrrole‐3‐carboxylate as the starting material. Compound 12 was devoid of antibacterial activity in vitro .