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Synthesis of 6‐phenyl and 6‐styrylthiazolo[3,2‐ b ] [1,2,4]triazoles
Author(s) -
Hénichart JeanPierre,
Houssin Raymond,
Bernier JeanLuc
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230555
Subject(s) - chemistry , thiazole , thio , conjugated system , yield (engineering) , combinatorial chemistry , stereochemistry , thiazoline , triazole , organic chemistry , polymer , materials science , metallurgy
Thiazole rings have been often encountered in the structure of antibiotic or antitumor drugs. An easy synthesis of them has revealed itself necessary in order to elucidate the mechanism of action of these naturally occurring substances. A method of preparation of conjugated b‐ethylenic thiazole[3,2‐ b ] [1,2,4]triazoles by heating a 3‐thio substituted [1,2,4]triazole in the presence of polyphosphoric acid is reported here, giving the expected product in a 60% yield.