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Synthesis of new spirobenzazolines including a furo[3,4‐ b ]pyran ring system
Author(s) -
Coudert P.,
Couquelet J. M.,
Tronche P.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230554
Subject(s) - chemistry , pyran , ring (chemistry) , stereochemistry , analgesic , medicinal chemistry , organic chemistry , pharmacology , medicine
A series of 4,5‐dihydrofuro[3,4‐ b ]pyran‐6‐spiro‐2′‐benzazolines 3 were prepared by reaction of 4,4‐dimethyl‐2,6‐dioxo‐4,5‐dihydrofuro[3,4‐ b ]pyran 1 with o ‐phenylenediamine, o ‐aminophenol, o ‐aminothiophenol or their derivatives. Most of these compounds exhibited a significant analgesic activity.
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