Synthesis of 4‐Aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridinedicarboxylates | Zendy

Kim Dong H. | Zendy

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Synthesis of 4‐Aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridinedicarboxylates

Author(s) -

Kim Dong H.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230553

Subject(s) - chemistry , trifluoromethyl , aryl , pyridine , piperidine , dicarboxylic acid , organic chemistry , phosphorus , medicinal chemistry , alkyl

Treatment of 4‐aryl‐2,6‐dihydroxy‐2,6‐bis(trifluoromethyl)‐3,5‐piperidinedicarboxylic acid esters with phosphorus oxychloride in pyridine afforded 4‐aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridine dicarboxylic acid esters which were reported originally by Balicki and Nantka‐Namirski, but were later proven to be 4‐aryl‐2,6‐dihydroxy‐2,6‐bis(trifluoromethyl)‐3,5‐piperidine dicarboxylic acid esters.

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