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Synthesis of 4‐Aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridinedicarboxylates
Author(s) -
Kim Dong H.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230553
Subject(s) - chemistry , trifluoromethyl , aryl , pyridine , piperidine , dicarboxylic acid , organic chemistry , phosphorus , medicinal chemistry , alkyl
Treatment of 4‐aryl‐2,6‐dihydroxy‐2,6‐bis(trifluoromethyl)‐3,5‐piperidinedicarboxylic acid esters with phosphorus oxychloride in pyridine afforded 4‐aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridine dicarboxylic acid esters which were reported originally by Balicki and Nantka‐Namirski, but were later proven to be 4‐aryl‐2,6‐dihydroxy‐2,6‐bis(trifluoromethyl)‐3,5‐piperidine dicarboxylic acid esters.