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Synthesis of furazano‐substituted 1,5‐diazepines
Author(s) -
Fischer John W.,
Atkins Ronald L.,
Nissan Robin A.,
LoweMa Charlotte K.,
Decker David L.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230552
Subject(s) - chemistry , ketone , methyl ketone , lewis acids and bases , methyl vinyl ketone , organic chemistry , medicinal chemistry , catalysis
A series of furazano‐substituted 1,5‐diazepines have been synthesized from the reaction of a methyl ketone and 3,4‐diaminofurazan in the presence of a mild Lewis acid. The reaction was found to be regiospecific. Other ketone substrates also yielded diazepines, however, these products were found to be unstable and decomposed upon contact with air.