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The reaction of pyridazinones with nucleophiles. An unusual reaction with cyanide
Author(s) -
Badger Edward W.,
Moos Walter H.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230551
Subject(s) - chemistry , nucleophile , cyanide , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis
Studies on the synthesis of pyridazinone analogues of pyridone cardiotonics are reported. The synthetic scheme involves the reaction of pyridazinones and chloropyridazinones with nucleophiles. Addition occurred twice with cyanide as the nucleophile, thus providing a novel dicyanopyridazinone.