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Reaction of 6‐ethylamino‐3‐methyluracil with nitrobenzenes
Author(s) -
Harayama Takashi,
Jinno Hideto,
Tezuka Yasuhiro,
Yoneda Fumio
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230549
Subject(s) - chemistry , nitrobenzene , yield (engineering) , uracil , potassium carbonate , medicinal chemistry , organic chemistry , biochemistry , catalysis , dna , materials science , metallurgy
Reaction of 6‐ethylamino‐3‐methyluracil ( 1 ) with nitrobenzenes in hexamethylphosphoric triamide gave isoalloxazines in 3.8–18 percent yield. In the presence of potassium carbonate, reaction of 1 with o ‐fluoronitrobenzene afforded 5‐substituted uracil 3 in moderate yield.