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Synthesis of pyrido[1′,2′:1,2]imidazo[4,5‐ b ]pyrazines from 2,3‐dichloro‐5,6‐dicyanopyrazine with 2‐aminopyridines
Author(s) -
Suzuki Toshinobu,
Nagae Yasushi,
Mitsuhashi Keiryo
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230533
Subject(s) - chemistry , aminopyridines , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry
Novel synthesis of the title compounds by the facile cyclization between 2,3‐dichloro‐5,6‐dicyanopyrazine and various 2‐aminopyridines under relatively mild conditions is described. The reactivity depended on the basicity of 2‐aminopyridines.