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Methylx derivatives of tetrahydrobenzo‐ and benzofurocoumarins, a new class of potential photoreagents toward dna
Author(s) -
Rodighiero P.,
Palumbo M.,
Magno S. Marciani,
Manzini P.,
Gia O.,
Piro R.,
Guiotto A.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230530
Subject(s) - furocoumarin , chemistry , ring (chemistry) , benzofuran , furan , moiety , psoralen , stereochemistry , double bond , cyclohexene , dna , combinatorial chemistry , organic chemistry , biochemistry , catalysis
A number of new tetracyclic furocoumarin derivatives with a linear structure or with various angular arrangements, were synthetized. The new compounds are characterized for having an additional cyclohexene or phenyl ring condensed at the 4′,5′ double bond of the furan ring of the furocoumarin nucleus. The syntheses were performed starting from the appropriate hydroxycoumarins on which the tetrahydrobenzofuran or benzofuran moiety was built. Methyl groups have been introduced into positions which look most promising for enhancement of the photoreactivity of the compounds toward DNA.