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Synthesis and in vitro antimicrobial and antifungal properties of some novel 1,3,4‐thiadiazole and s ‐triazolo[3,4‐ b ][1,3,4]thiadiazole derivatives
Author(s) -
Omar A.Mohsen M. E.,
Aboulwafa Omaima M.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230514
Subject(s) - thiadiazoles , chemistry , antimicrobial , candida albicans , antifungal , in vitro , staphylococcus aureus , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , microbiology and biotechnology , bacteria , biochemistry , genetics , biology
A novel series of 2‐arylthiocarbamoylhydrazino‐5‐phenyl‐1,3,4‐thiadiazoles III‐VII was synthesized and cyclodesulfurized into the corresponding 3‐arylamino‐6‐phenyl‐ s ‐triazolo[3,4‐ b ][1,3,4]thiadiazoles VIII‐XII with DCCD. Some of the products were found to be only moderately active against Staphylococcus aureus and Candida albicans .