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Phosphoryl chloride induced ring contraction of 1,4‐benzodiazepinones to chloromethylquinazolines
Author(s) -
Combs Donald W.,
Press Jeffery B.,
Mulvey Dennis,
GrayNunez Yolanda,
Bell Stanley C.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230458
Subject(s) - chemistry , contraction (grammar) , chloride , ring (chemistry) , phosphoryl chloride , medicinal chemistry , stereochemistry , organic chemistry , medicine
A ring contraction of 1,4‐benzodiazepin‐2‐one to 2‐chloromethylquinazoline in phosphoryl chloride is described. The intermediacy of an aziridinoquinazoline is proposed.