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Reaction of 2‐acetyltetralone with some esters of benzoic acid
Author(s) -
Arcoleo A.,
Gottuso M.,
Giammona G.,
Fontana G.,
Abbate G.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230452
Subject(s) - chemistry , benzoic acid , chlorine atom , alkoxy group , chlorine , nucleophilic substitution , nucleophile , pyran , medicinal chemistry , organic chemistry , catalysis , alkyl
In order to investigate the pharmacological screening of a number of pyran‐4‐ones their synthesis by cyclization with sulphuric acid of the corresponding 1,3,5‐triketones has been carried out with high yields. In the course of preparation of the latter the reaction of 2‐acetyltetralone with some esters of benzoic acid derivatives has been studied and in particular, for a number of them, an interesting nucleophilic substitution of a chlorine atom with an alkoxy group on a benzenic nucleus has been evidenced.