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Heterocyclic rearrangements. Synthesis of 1,2,4‐oxadiazolo[2,3‐ a ]pyrimidinium systems and their ring opening into pyrimidine N ‐oxides
Author(s) -
Buscemi Silvestre,
Macaluso Gabriella,
Frenna Vincenzo,
Vivoicolò
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230442
Subject(s) - chemistry , acetylacetone , pyrimidine , ring (chemistry) , perchloric acid , oxadiazole , medicinal chemistry , stereochemistry , organic chemistry
Abstract The reaction of 3‐amino‐5‐phenyl‐(methyl‐)‐1,2,4‐oxadiazole with acetylacetone or benzoylacetone in the presence of perchloric acid has been studied. Synthesis of 1,2,4‐oxadiazolo[2,3‐α]pyrimidinium perchlorates and their ring opening reaction into aminopyrimidine N ‐oxides is reported.