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Synthesis of 2‐aryl‐6‐carbethoxythiazolo[4,5‐ c ]pyridine and 7‐chloro‐2‐phenylthiazolo[5,4‐ c ]pyridine
Author(s) -
Shafiee A.,
Ghazar H.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230441
Subject(s) - chemistry , pyridine , aryl , azide , medicinal chemistry , organic chemistry , alkyl
Starting from readily available 2‐aryl‐5‐formyl‐4‐mehtylthiazole, 2‐aryl‐6‐carbethoxythiazolo[4,5‐ c ]pyridine was prepared. β‐(2‐Phenylthiazol‐4‐yl)acrylic acid was converted to the corresponding azide (VI). Cyclization of compound VI afforded 2‐phenylthiazolo[5,4‐ c ]pyridin‐7(6 H )one. Reaction of the latter with phosphorous oxychloride gave 7‐chloro‐2‐phenylthiazolo[5,4‐ c ]pyridine.