Premium
Novel syntheses of 2,3‐dihydro‐5 H ‐1,4‐benzoxathiepins and 1,2,3,5‐tetrahydro‐4,1‐benzothiazepines
Author(s) -
Ishibashi Hiroyuki,
Okada Motofumi,
Akiyama Atsuko,
Nomura Kazuyuki,
Ikeda Masazumi
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230439
Subject(s) - chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry , computational chemistry
2,3‐Dihydro‐5 H ‐1,4‐benzoxathiepins were prepared by intramolecular Friedel‐Crafts reactions of ethyl α‐[2‐(aryloxy)ethylthio]‐α‐chloroacetates or by acid‐catalyzed cyclizations of ethyl α‐[2‐(aryloxy)ethylsulfinyl]‐acetate. 1,2,3,5‐Tetrahydro‐4,1‐benzothiazepines were similarly prepared.