Premium
A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones
Author(s) -
Heindel Ned D.,
Lacey C. Jeffrey,
Egolf Roger,
Mease Belle N.,
Schray Keith J.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230425
Subject(s) - chemistry , nitro , aryl , sulfide , sulfur , peroxide , oxidation process , sulfone , medicinal chemistry , cleavage (geology) , sulfoxide , redox , organic chemistry , combinatorial chemistry , alkyl , geotechnical engineering , pulp and paper industry , fracture (geology) , engineering
Aryl imidazolyl sulfones bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide‐effected oxidation at sulfur was invariably accompanied by some cleavage‐oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.