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Synthesis and fluorescence of N ‐substituted‐1,8‐naphthalimides
Author(s) -
Middleton Richard W.,
Parrick John,
Clarke Eric D.,
Wardman Peter
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230337
Subject(s) - chemistry , fluorescence , nucleus , combinatorial chemistry , medicinal chemistry , photochemistry , physics , quantum mechanics , biology , microbiology and biotechnology
A number of novel N ‐substituted‐1,8‐naphthalimides have been prepared and their fluorescence yields measured in water at p H 7.4. The type of substitutent and the substitution pattern on the naphthalimide nucleus produce markedly different fluorescence yields, (quantum efficiencies, ø varying from ø = 0‐0037 for N ‐(3‐N'‐morpholino‐1‐propyl)‐4‐amino‐3‐methoxy‐1,8‐naphthalirnide (7) to ø = 0–77 for N ‐(3‐bromopropyl)‐4‐acetamido‐1,8‐naphthalimide (31).

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