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The identification of 10 and 11 substituted 7 H ‐benzimidazo[2,1‐ a ]benz[ de ]isoquinolin‐7‐ones through 1 N NOE studies on their methyl p ‐toluenesulfonate salts
Author(s) -
Campbell Jack B.,
Lavagnino Edward R.,
Paschal Jonathan W.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230323
Subject(s) - chemistry , stereochemistry , medicinal chemistry
The spectral similarities of 10 and 11 substituted 7 H ‐benzimidazo[2,1‐ a ]benz[ de ]isoquinolin‐7‐ones hinder the identification of the individual isomers. Preparation of the 13‐methyl p ‐toluenesulfonate salts of these compounds has allowed the assignment by the use of NOE techniques. Saturation of the N ‐methyl caused an NOE at H‐12. The coupling pattern of H‐12 then provides identification of the compound.