Syntheses and reactions of some 1‐substituted‐7‐alkyl‐2‐thioxopurines: X‐Ray structure of 6‐methylamino‐7‐nonyl‐2‐thioxopurine | Zendy

Grözinger Karl G. | Zendy; Onan Kay D. | Zendy

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Syntheses and reactions of some 1‐substituted‐7‐alkyl‐2‐thioxopurines: X‐Ray structure of 6‐methylamino‐7‐nonyl‐2‐thioxopurine

Author(s) -

Grözinger Karl G.,

Onan Kay D.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230319

Subject(s) - chemistry , alkyl , isothiocyanate , x ray , medicinal chemistry , product (mathematics) , phenyl isothiocyanate , stereochemistry , organic chemistry , physics , quantum mechanics , geometry , mathematics

Several 1‐substituted‐7‐alkyl‐2‐thioxopurines 8,9,10 were synthesized by the reaction of isothiocyanates with 1‐alkyl‐4‐amino‐5‐cyanoimidazoles 3 . Treatment of 3 with methyl isothiocyanate gave the Dimroth rearranged product 6‐methylamino‐7‐alkyl‐2‐thioxopurines 11 . The structure of 11 was unambiguously defined by X‐ray crystallography.

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