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Syntheses and reactions of some 1‐substituted‐7‐alkyl‐2‐thioxopurines: X‐Ray structure of 6‐methylamino‐7‐nonyl‐2‐thioxopurine
Author(s) -
Grözinger Karl G.,
Onan Kay D.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230319
Subject(s) - chemistry , alkyl , isothiocyanate , x ray , medicinal chemistry , product (mathematics) , phenyl isothiocyanate , stereochemistry , organic chemistry , physics , quantum mechanics , geometry , mathematics
Several 1‐substituted‐7‐alkyl‐2‐thioxopurines 8,9,10 were synthesized by the reaction of isothiocyanates with 1‐alkyl‐4‐amino‐5‐cyanoimidazoles 3 . Treatment of 3 with methyl isothiocyanate gave the Dimroth rearranged product 6‐methylamino‐7‐alkyl‐2‐thioxopurines 11 . The structure of 11 was unambiguously defined by X‐ray crystallography.