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Reactivity of pyrazolo[4,3‐ c ][1,2,5]oxadiazin‐3(5 H )‐ones toward C ‐nucleophiles: Synthesis of pyrazolo[3,4‐ b ]pyrazines
Author(s) -
Giori P.,
Veronese A. C.,
Poli T.,
Vicentini C. B.,
Manfrini M.,
Guarneri M.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230255
Subject(s) - chemistry , carbanion , reactivity (psychology) , nucleophile , methylene , medicinal chemistry , stereochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
The reaction of pyrazolo[4,3‐ c ][1,2,5]oxadiazin‐3(5 H )‐ones 1 with carbanions prepared in situ from compounds containing an activated methylene group afforded pyrazolo[3,4‐ b ]pyrazines 4–13 in good yields. The possible reaction mechanism is proposed and discussed.