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Synthesis of 6‐arylazo‐substituted 5‐hydroxy‐2‐hydroxymethyl‐4‐pyridones and related compounds
Author(s) -
Imafuku Kimiaki,
Matsuura Hiromichi
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230205
Subject(s) - chemistry , diazomethane , hydroxymethyl , medicinal chemistry , organic chemistry
5‐Hydroxy‐2‐hydroxymethyl‐4‐pyridone ( 1 ) and 5‐hydroxy‐2‐hydroxymethyl‐1‐methyl‐4‐pyridone ( 2 ) reacted with arenediazonium salts to give 6‐arylazo‐substituted compounds 3a‐d and 4a‐d , respectively. Compounds 3a‐d were methylated with diazomethane to afford 6‐arylazo‐2‐hydroxymethyl‐4,5‐dimethoxypyridines 5a‐d .
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