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Stereo structures and absolute configurations of reaction products of dl ‐1,3‐dimethylthymine epoxide with l‐amino acid ethyl esters
Author(s) -
Harayama Takashi,
Yanada Reiko,
Taga Tooru,
Machida Katsunosuke,
Yoneda Fumio
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230159
Subject(s) - chemistry , diastereomer , epoxide , optically active , absolute configuration , stereochemistry , ethyl ester , organic chemistry , catalysis
Each reaction of dl ‐1,3‐dimethylthymine epoxide ( 1 ) with L‐amino acid ethyl esters (Pro‐OEt, Met‐OEt, Phe‐OEt, and Trp‐OEt) afforded the respective four optically active diastereomers 4–7 , stereo structures of which were definitely elucidated as shown in Chart 1 by an X‐ray analysis of 4A and chemical means.