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Studies on pyrrolidinones. A convenient synthesis of 2‐methyl‐5‐(5‐oxo‐1‐benzyl‐2‐pyrrolidinyl)‐1,3,4‐oxadiazole
Author(s) -
Rigo Benoǐt,
Couturier Daniel
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230152
Subject(s) - chemistry , methanesulfonic acid , pyrrolidinones , oxadiazole , hydrazide , dehydration , organic chemistry , phosphoric acid , biochemistry
2‐Methyl‐5‐(5‐oxo‐1‐benzyl‐2‐pyrrolidinyl)‐1,3,4‐oxadiazole is easily obtained by dehydration of N ‐acetyl‐1‐benzylpyroglutamic acid hydrazide with a methanesulfonic acid/phosphoric anhydride mixture.
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