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A conveneint synthesis of 1‐substituted‐2,5(4 H )‐piperazinediones
Author(s) -
Lovelette C. A.,
Geagan K.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230147
Subject(s) - chemistry , glycylglycine , acrylonitrile , methyl acrylate , acrylate , alanine , dipeptide , organic chemistry , medicinal chemistry , amino acid , glycine , polymer , monomer , biochemistry , copolymer
1‐Substituted‐2,5(4 H )‐piperazinediones are prepared by the Michael addition of acrylonitrile and methyl‐acrylate and glycylglycine, DL‐alanyl‐DL‐alanine and DL‐alanyl‐DL‐phenylalanine followed by cyclohydration in refluxing xylenes.