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An unexpected product from the cyclodesulfurization of 5‐[1‐(3‐methoxycarbonyl)thioureido]‐1‐(β‐D‐ribofuranosyl)imidazole‐4‐ carboxamide with dicyclohexylcarbodiimide
Author(s) -
Chern JiWang,
Groziak Michael P.,
Townsend Leroy B.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230131
Subject(s) - chemistry , imidazole , carboxamide , product (mathematics) , stereochemistry , medicinal chemistry , mathematics , geometry
Abstract The treatment of 5‐[1‐(3‐methoxycarbonyl)thioureido]‐1‐(β‐D‐ribofuranosyl)imidazole‐4‐carboxamide with N,N' ‐dicyclohexylcarbodiimide in N,N ‐dimethylformamide has afforded 4‐cyano‐5‐[1‐(3‐methoxycarbonyl)‐ureido]‐1‐(β‐D‐ribofuranosyl)imidazole.