Premium
Studies on pyrazines. 13 . Chlorination of 1‐hydroxy‐2(1 H )‐pyrazinones with phosphoryl chloride. Formation of 2,5‐dichloro‐3‐phenylpyrazine from 1‐hydroxy‐3‐phenyl‐2(1 H )‐pyrazinone
Author(s) -
Sato Nobuhiro
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230130
Subject(s) - chemistry , reagent , phosphoryl chloride , chloride , medicinal chemistry , stereochemistry , organic chemistry
The chlorination of 1‐hydroxy‐3‐phenyl‐2(1 H )‐pyrazinone with phosphoryl chloride proceeded to 5‐chloro‐3‐phenyl‐2( H )‐pyrazinone or 2,5‐dichloro‐3‐phenylpyrazine on heating to elevated temperatures. To define the mechanism of the novel formation, reactions of the parent or methyl‐substituted 1‐hydroxy‐2(1 H )‐pyraz‐inones with the same reagent were investigated.