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Heterocycles. Part VIII. Synthesis of new substituted benz[ g ]indazoles
Author(s) -
ElRayyes N. R.,
AlJawhary A.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230127
Subject(s) - chemistry , phenylhydrazine , methylhydrazine , indazole , tetralone , hydrazine (antidepressant) , acetylation , condensation , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , physics , thermodynamics , chromatography , gene
Aryl aldehydes I reacted with α‐tetralone to give the corresponding 2‐arylidene‐1‐tetralone II. Condensation of the latter chalcones with hydrazine, methylhydrazine and phenylhydrazine produced the corresponding benzo[ g ]indazoles III, V and VI respectively. Acetylation of the 2 H ‐benz[ g ]indazole derivatives III gave the corresponding 2‐acetylated compounds IV. The structure of all products was elucidated by chemical and spectroscopic methods.