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Synthesis of some new 5‐chloro‐7‐mercapto‐1‐methyl/phenyl‐1,2,4‐triazolo[4,5‐ b ]pyrazin‐2(1 H )‐ones and 5‐chloro‐3‐thiopyrazin‐2(1 H )‐one derivatives as possible antibacterial and antifungal agents
Author(s) -
Bhattacharya B. K.
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230123
Subject(s) - chemistry , antifungal , aryl , stereochemistry , thio , medicinal chemistry , antibacterial activity , bacteria , organic chemistry , alkyl , microbiology and biotechnology , genetics , biology
Several new 5‐chloro‐7‐mercapto‐1‐methyl/phenyl‐1,2,4‐triazolo[4,5‐6]pyrazin‐2(1/ H )‐ones V and their disul‐phides VI, 5‐chloro‐3‐mercapto‐2(1 H )‐pyrazinonones III, 5‐chloro‐3‐( N ‐aryl‐ N ‐acetylthioureido)‐1‐methyl/‐phenyl‐2(1 H )‐pyrazinones VII, 5‐chloro‐1‐methyl/phenyl‐3‐sulphonamido‐2(1 H )‐pyrazinones X and chloro‐2‐methyl/phenyl‐(3‐methyl)‐3‐thio‐2(1 H )‐pyrazinones XI were synthesized starting from 3,5‐dichloro‐1‐methyl/phenylpyrazin‐2(1 H )‐ones I. Fifteen of these compounds were screened for their antibacterial and antifungal activity against two bacteria B. subtilis and S. aureus , and two fungi A. niger and H. oryzae. A possible structure activity relationship is given.