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Synthesis and spectral behavior of 6‐phenyl‐5,6,7,8‐tetrahydro‐4 H ‐1,3,6‐dioxazocines using NMR
Author(s) -
Nishiyama Tomihiro,
Iwasaki Yoshiaki,
Yamada Fukiko
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230114
Subject(s) - chemistry , aldehyde , ketone , chemical shift , condensation , nmr spectra database , stereochemistry , medicinal chemistry , organic chemistry , spectral line , catalysis , physics , astronomy , thermodynamics
Heterocyclic compounds of four 6‐phenyl‐5,6,7,8‐tetrahydro‐4 H ‐1,3,6‐dioxazocines have been synthesized by condensation of the corresponding N,N ‐bis(2‐hydroxyethyl)‐ or N,N ‐bis(2‐hydroxypropyl)anilines with aldehyde or ketone in the presence of acid. The pmr and cmr spectra of these compounds were recorded to determine their stereochemical structures. On the basis of the chemical shifts due to the γ‐effects, the stereochemical structures are discussed.