Convenient preparative methods for  N ‐aryl‐γ‐pyridones from γ‐pyrones | Zendy

Looker James H. | Zendy; Cliffton Michael D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Convenient preparative methods for N ‐aryl‐γ‐pyridones from γ‐pyrones

Author(s) -

Looker James H.,

Cliffton Michael D.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230102

Subject(s) - chemistry , aniline , hydrochloride , hydrochloric acid , aqueous solution , aryl , yield (engineering) , amine gas treating , hydroxymethyl , organic chemistry , medicinal chemistry , alkyl , materials science , metallurgy

2‐Hydroxymethyl‐5‐methoxy‐4‐ H ‐pyran‐4‐one ( 1 ) reacts with aniline and six aniline derivatives in very dilute aqueous hydrochloric acid at reflux temperature to give the N ‐aryl‐γ‐pyridone. A second procedure utilizes the aromatic amine hydrochloride by reacting it with 1 in aqueous medium at reflux temperature. p‐N itroaniline hydrochloride and 1 give the N ‐aryl‐γ‐pyridone in 65% yield, as opposed to 12% from the dilute acid procedure.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research