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Heterocycles of biological importance. Part 2 . Novel synthesis and pharmacological evaluation of 5‐amino‐3‐alkyl‐1‐(2‐pyridyl)pyrazoles and 5‐amino‐3‐phenyl‐1‐(2‐pyridyl)pyrazole from allenic or acetylenic nitriles and 2‐hydrazinopyridine
Author(s) -
Fomum Z. Tanee,
Ifeadike P. Ngozi
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220629
Subject(s) - chemistry , pyrazole , alkyl , yield (engineering) , amino acid , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , materials science , metallurgy
2‐Hydrazinopyridine reacts with allenic and acetylenic nitriles to give 5‐amino‐3‐alkyl‐1‐(2‐pyridyl)pyrazoles 6 in excellent yields. One of these compounds, 6e has been shown to possess anticonvulsant and anti‐electroshock properties. Phenyl propynenitrile also reacts with hydrazinopyridine to give 5‐amino‐3‐phenyl‐1‐(2‐pyridyl)pyrazole ( 11 ) in quantitative yield.