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P‐N Compounds. 27 . Synthesis of a 5‐amino‐4,6‐dioxo‐1,3,5,2‐triazaphosphorine 2‐oxide
Author(s) -
Cates Lindley A.,
Li VenShun
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220618
Subject(s) - chemistry , semicarbazide , oxide , dimethylhydrazine , medicinal chemistry , organic chemistry , combinatorial chemistry , medicine , colorectal cancer , cancer
Abstract Heating N 4 ‐phenylphosphinyl‐bis‐( N 1 ‐dimethyl) semicarbazide in the presence, but not in the absence, of iodomethane gave 2‐phenyl‐5‐dimethylamino‐4,6‐dioxo‐1,3,5,2‐triazaphosphorine 2‐oxide and a mechanism for this reaction is proposed. The compound was also prepared by the addition of 1,1‐dimethylhydrazine to phenylphosphonic diisocyanate. Treatment of the product with excess iodomethane gave a polymeric material and 1,1,1‐trimethylhydrazinium iodides.