Pyridazines.  XXV  . Formation of 2‐benzoyl‐2,5‐dihydro‐3‐pyridazinecarbonitrile derivatives in the reissert reaction of pyridazines | Zendy

Dostal Wolfgang | Zendy; Heinisch Gottfried | Zendy

Premium

Pyridazines. XXV . Formation of 2‐benzoyl‐2,5‐dihydro‐3‐pyridazinecarbonitrile derivatives in the reissert reaction of pyridazines

Author(s) -

Dostal Wolfgang,

Heinisch Gottfried

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220615

Subject(s) - chemistry , benzoyl chloride , pyridazine , cyanide ion , potassium cyanide , cyanide , medicinal chemistry , chloride , potassium , solvent , organic chemistry

Pyridazines 1a, b on treatment with potassium cyanide/benzoyl chloride in a mixed solvent system gave 2‐benzoyl‐2,5‐dihydro‐3‐pyridazinecarbonitriles 3a, b together with products resulting from attack of one mole of cyanide ion and three moles of benzoyl chloride ( 5a, b ). The structures of these novel compounds are proved. A plausible reaction mechanism is proposed, involving rearrangement of initially formed 2a, b into 3a, b . Furthermore, the synthesis of the pyridazine Reissert compound 2a is reported.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research