An NMR study of the decomposition of a 2,2‐disubstituted thiazolidine. Kinetic evidence for a schiff base intermediate | Zendy

Pesek Joseph J. | Zendy; NiyatiShirkhodaee Fatemeh | Zendy; Kashefi Mohammad | Zendy

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An NMR study of the decomposition of a 2,2‐disubstituted thiazolidine. Kinetic evidence for a schiff base intermediate

Author(s) -

Pesek Joseph J.,

NiyatiShirkhodaee Fatemeh,

Kashefi Mohammad

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220550

Subject(s) - chemistry , schiff base , thiazolidine , decomposition , base (topology) , kinetic energy , entropy of activation , medicinal chemistry , computational chemistry , organic chemistry , stereochemistry , reaction rate constant , kinetics , mathematical analysis , physics , mathematics , quantum mechanics

The p H‐rate profile for the decomposition of 2,2,5,5‐tetramethyl‐4‐thiazolidinecarboxylic acid is used to identify the presence of a Schiff base intermediate. Activation parameters for the reaction are reported at various p H's and in particular the negative values of entropy support the presence of a carbinolamine in the rate‐determining step.

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