Cyclocondensation of 2‐hydrazinoperimidine with diethyl oxalate and ethyl pyruvate | Zendy

Liu KangChien | Zendy; Chen HsiuHo | Zendy

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Cyclocondensation of 2‐hydrazinoperimidine with diethyl oxalate and ethyl pyruvate

Author(s) -

Liu KangChien,

Chen HsiuHo

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220545

Subject(s) - chemistry , yield (engineering) , acetic acid , oxalate , elemental analysis , medicinal chemistry , organic chemistry , nuclear chemistry , metallurgy , materials science

Refluxing 2‐hydrazinoperimidine (1) with excess amount of diethyl oxalate (2a) gave ethyl 1 H ‐1,2,4‐triazolo[4,3‐ a ]perimidine‐3‐carboxylate (4a) in 84% yield. On the other hand, heating 1 with ethyl pyruvate (2b) in glacial acetic acid afforded 3‐methyl‐1,2,4‐triazino[4,3‐ a ]perimidin‐4(1 H )‐one (6b) in 92% yield. Structures of the products were investigated by spectral and elemental analysis.

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