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Synthesis of 2‐(1‐methyl‐4‐piperylid‐3‐ene)‐9,10‐dihydro‐4 H ‐benzo[4,5]‐ cyclohepta[1,2‐ b ]thiophen‐10‐one, a new potential antiasthmatic analogue of zaditene
Author(s) -
Majchrzak Michal W.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220511
Subject(s) - chemistry , thiophene , stereochemistry , ene reaction , medicinal chemistry , organic chemistry
The title compound has been prepared in four steps from readily available starting material. The key reaction is the metallation of 10‐methoxy‐4 H ‐benzo[4,5]cyclohepta[1,2‐ b ]thiophene, which occurs exclusively at the desired 2 position.