Synthesis of some 2‐(heteroarylamino)benzimidazoles and their cyclization with phosgene | Zendy

Bossio Ricardo | Zendy; Marcaccini Stefano | Zendy; Parrini Valerio | Zendy; Pepino Roberto | Zendy

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Synthesis of some 2‐(heteroarylamino)benzimidazoles and their cyclization with phosgene

Author(s) -

Bossio Ricardo,

Marcaccini Stefano,

Parrini Valerio,

Pepino Roberto

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220448

Subject(s) - chemistry , phosgene , thiazole , pyrazine , pyridine , ring (chemistry) , mass spectrum , medicinal chemistry , benzimidazole , stereochemistry , mass spectrometry , organic chemistry , chromatography

2‐(Benzimidazol‐2‐ylamino)pyridine (4a) , 2‐(benzimidazol‐2‐ylamino)pyrazine (4b) , and 2‐(benzimidazol‐2‐ylamino)thiazole (4c) underwent a ring‐closure reaction on treatment with phosgene affording 6 H ‐pyrimido‐[1′,2′:5,4][1,3,5]triazino[1,2‐ a ]benzimidazol‐6‐one (1a) , 6 H ‐pyrazino[1′,2′:5,4][1,3,5]triazino[1,2‐ a ]benzimidazol‐6‐one (1b) , and 5 H ‐thiazolo[2′,3′:4,5][1,3,5]triazino[1,2‐ a ]benzimidazol‐5‐one (1c) respectively. The structure of these hitherto unknown heterocyclic systems was confirmed by their ir and mass spectra.

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