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Synthesis of the 7‐deaza and 5‐aza‐7‐deaza purine analogs of the antiherpes agent 9‐[(1,3‐dihydroxy‐2‐propoxy)methyl]guanine (DHPG)
Author(s) -
Mcgee Danny P. C.,
Martin John C.,
Verheyden Julien P. H.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220444
Subject(s) - chemistry , purine , guanine , purine analogue , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , enzyme , nucleotide , gene
Synthesis of 2‐amino‐7‐[(1,3‐dihydroxy‐2‐propoxy)methyl]pyrrolo[2,3‐ d ]pyrimidin‐4‐one (3) a 7‐deaza purine analogue and 2‐amino‐8‐[(1,3‐dihydroxy‐2‐propoxy)methyl]imidazo[1,2‐ a]‐s ‐triazin‐4‐one (4) a 5‐aza‐7‐deaza purine analogue of DHPG (2) are reported.