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Synthesis of pyrrolo[2,1‐ c ][1,4]benzoxazepines. 1. A novel heterocyclic ring system
Author(s) -
Effland Richard C.,
Davis Larry
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220429
Subject(s) - chemistry , formylation , ring (chemistry) , nucleophile , derivative (finance) , mannich reaction , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , financial economics , economics
The synthesis of a novel pyrrolo[2,1‐ c ][1,4]benzoxazepine ring system (II) by a nucleophilic aromatic fluoride displacement‐cyclization is described. Aminoalkyl derivatives were prepared by either the Mannich reaction, or Vilsmeier formylation to provide the 3‐formyl derivative which was further elaborated.