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Synthesis of new 1,2,4‐triazolo[4,3‐ b ]pyridazines and related compounds
Author(s) -
Sircar Ila
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220424
Subject(s) - chemistry , bicyclic molecule , hydrazine (antidepressant) , stereochemistry , pyridazine , biochemistry
The synthesis of novel 6‐[4‐(1 H ‐imidazol‐1‐yl)phenyl]‐1,2,4‐triazolo[4,3‐ b ]pyridazines 8a‐f and related compounds is described. Although the intermediate hydrazine derivatives 7 and 9 possess good positive inotropic activity, the fused bicyclic pyridazines 8a‐f are significantly less potent than the 3(2 H )‐pyridazinone 5. Compounds 8a‐f are potent but nonselective inhibitors of cardiac phosphodiesterase.