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Synthetic models related to DNA intercalating molecules: Preparation of 9‐aminoacridines linked to the nucleotide bases adenine, guanine and thymine
Author(s) -
Constant J. F.,
Carden B. M.,
Lhomme J.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220422
Subject(s) - chemistry , guanine , thymine , dna , nucleobase , nucleotide , ring (chemistry) , cytosine , stereochemistry , intercalation (chemistry) , molecule , nucleic acid , combinatorial chemistry , biochemistry , organic chemistry , gene
A series of novel compounds were prepared in which the aromatic ring of the drug quinacrine (2‐methoxy‐6‐chloro‐9‐alkylaminoacridine) is linked to the nucleotide bases adenine, guanine and thymine by penta‐and hexamethylene bridges.