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New synthesis of 5,6,7,8‐tetrahydro‐4 H ‐thieno[2,3‐ d ]azepine
Author(s) -
Fréhel Daniel,
Badorc Alain,
Pereillo JeanMarie,
Maffrand JeanPierre
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220416
Subject(s) - azepine , chemistry , ethylamine , derivative (finance) , pyridinium , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , financial economics , economics
This paper describes two new access routes to 5,6,7,8‐tetrahydro‐4 H ‐thieno[2,3‐ d ]azepine from 2‐(2‐thienyl)ethylamine or its N ‐(2‐chlorobenzyl) derivative. One of these two syntheses involves a new ring expansion from a 6,7‐dihydro[3,2‐ c ]pyridinium derivative, chloromethylated in position 4.