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Derivatives of benzo[5,6]cyclohepta[1,2‐ b ]thiophene. Synthesis of 2,3,7,8‐tetrahydro‐3‐oxothieno[1,2‐ b ]cyclohepta[5,6,7‐ de ]isoquinoline and 1,2,3,7,8,11b‐hexahydro‐3‐oxothieno[1,2‐ b ]cyclohepta[5,6,7‐ de ]isoquinoline
Author(s) -
Sarriá Eva,
Vega Salvador
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220407
Subject(s) - chemistry , thiophene , wittig reaction , isocyanate , medicinal chemistry , stereochemistry , organic chemistry , polyurethane
The synthesis of the title compounds was carried out by cyclization via isocyanate of ( E )‐4,5‐dihydro‐10 H ‐benzo[5,6]cyclohepta[1,2‐ b ]‐thiophene‐10‐ylideneacetic acid and 4,5‐dihydro‐10 H ‐benzo[5,6]cyclohepta[1,2‐ b ]‐thiophene‐10‐ylacetic acid respectively, which were obtained by the Wadsworth‐Emmons modification of the Wittig reaction of 4,5‐dihydro‐10 H ‐10‐oxobenzo[5,6]cyclohepta[1,2‐ b ]thiophene and triethyl phosphonacetate. The structures of these new compounds are described.