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Reaction of 6‐phenyl‐2‐( p ‐toluenesulfonyl)‐3( 2H )pyridazinone with grignard reagents
Author(s) -
Kashima Choji,
Katoh Akira,
Fukasawa Miyuki,
Omote Yoshimori
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220362
Subject(s) - chemistry , reagent , grignard reagent , grignard reaction , medicinal chemistry , alcohol , ring (chemistry) , organic chemistry
6‐Phenyl‐2‐( p ‐toluenesulfonyl)‐3( 2H )pyridazinone (I) reacted with Grignard reagents to give 5‐substituted 4,5‐dihydro‐3( 2H )pyridazinones II and two types of dihydropyridazines, III and IV. The ratio of II, III, and IV was sensitively dependent on the reaction conditions. Further, by quenching the reaction mixture with alcohol, the ring‐opened product VII was mainly isolated.