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Potential anticonvulsants. X. (Reissert compounds studies. LI.) 1‐methyl‐4‐(1‐isoquinolinyl)piperidin‐4‐ol and related compounds
Author(s) -
Popp Frank D.,
Kant Joydeep
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220353
Subject(s) - chemistry , isoquinoline , hydrolysis , organic chemistry , medicinal chemistry
Abstract The anion of isoquinoline Reissert Compounds has been condensed with 4‐piperidones and pyridinecarb‐oxaldehydes to give esters which are easily hydrolyzed to alcohols. The anticonvulsants activity of these alcohols is reported and several are active in the maximal electroshock seizure test.